Functional involvement of RINF, Retinoid-Inducible Nuclear Factor (CXXC5), in normal and tumoral human myelopoiesis Short title: RINF expression is required for myelopoiesis
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Functional involvement of RINF, Retinoid-Inducible Nuclear Factor (CXXC5), in normal and tumoral human myelopoiesis Short title: RINF expression is required for myelopoiesis Frédéric Pendino, Eric Nguyen, Inge Jonassen, Bjarte Dysvik, Abdulkader Azouz, Michel Lanotte, Evelyne Ségal-Bendirdjian, and Johan R. Lillehaug. Department of Molecular Biology, University of Bergen, Norway; INSERM U685, Hôpital Saint-Louis, Institut Universitaire d’Hématologie, Paris, France; Bergen Center for Computational Science, Bergen, Norway. Corresponding author: Frédéric Pendino, INSERM U685, Hôpital Saint-Louis, Institut Universitaire d’Hématologie, 1, avenue Claude Vellefaux, 75010, Paris, France; e-mail: [email protected]. Phone: +33157276743, Fax: +33142409557 Scientific Category: HEMATOPOIESIS AND STEM CELLS Blood First Edition Paper, prepublished online January 30, 2009; DOI 10.1182/blood-2008-07-170035
منابع مشابه
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differ...
متن کاملCXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia
The retinoid-responsive gene CXXC5 localizes to the 5q31.2 chromosomal region and encodes a retinoid-inducible nuclear factor (RINF) that seems important during normal myelopoiesis. We investigated CXXC5/RINF expression in primary human acute myeloid leukemia (AML) cells derived from 594 patients, and a wide variation in CXXC5/RINF mRNA levels was observed both in the immature leukemic myelobla...
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BACKGROUND We have previously described the essential role of the retinoid-inducible nuclear factor (RINF) during differentiation of hematopoietic cells and suggested its putative involvement in myeloid leukemia and preleukemia. Here, we have investigated whether this gene could have a deregulated expression in malignant tissues compared with their normal tissues of origin and if this potential...
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Neutrophil granulocytes (Gs) represent highly abundant and short-lived leukocytes that are constantly regenerated from a small pool of myeloid committed progenitors. Nuclear receptor (NR) family members are ligand-activated transcription factors that play key roles in cellular proliferation and differentiation processes including myelopoiesis. Retinoid X receptor alpha (RXRalpha) represents the...
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In recent years a novel family of interferon (IFN)-inducible nuclear proteins has been identified in both mouse and humans and implicated in the control of myeloid differentiation. Recent evidence suggests that this role may be mediated by an effect on cell cycle regulation through interaction with known transcriptional regulators. Our laboratory first identified a nuclear protein designated IF...
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تاریخ انتشار 2009